Current issue subscribe archive rss & alerts contact loading article tools view pdf cite this article e-mail this article share this article send a letter information on reuse standard abbreviations author information find articles by griffing, g. discount viagra or viagra T. In: jci | pubmed | google scholar find articles by brownie, a.
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E-mail the jci published in volume 76, issue 1 (july 1985) j clin invest. viagra comparison with viagra 1985;76(1):163â€“169.
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Copyright â© 1985, the american society for clinical investigation.
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Research article plasma immunoreactive gamma melanotropin in patients with idiopathic hyperaldosteronism, aldosterone-producing adenomas, and essential hypertension.
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G t griffing, b berelowitz, m hudson, r salzman, j a manson, s aurrechia, j c melby, r c pedersen and a c brownie published july 1985 a non-acth aldosterone-stimulating factor(s) has been implicated in the pathogenesis of idiopathic hyperaldosteronism (iha).
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Although this factor has not been fully characterized, some evidence suggests that it may be related to a pro-gamma-melanotropin (pro-gamma-msh), derived from the nh2-terminal region of pro-opiomelanocortin.
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In the present study, plasma immunoreactive (ir-) gamma-msh levels at 0800 h in patients with iha were evaluated (90 +/- 17 fmol/ml; range: 13-173 fmol/ml) and found to be significantly higher (p less than 0. typical cost viagra 05) than those in subjects with aldosterone-producing adenomas (33 +/- 8 fmol/ml), essential hypertension (33 +/- 6 fmol/ml), and normotensive controls (19 +/- 2 fmol/ml). discount viagra or viagra Seven of nine iha subjects had circulating ir-gamma-msh levels above the normal range (greater than 35 fmol/ml).
In plasmas sampled at 1200 h, ir-gamma-msh was significantly higher in patients with iha (95 +/- 26 fmol/ml) and adenomas (63 +/- 23 fmol/ml), as compared with essential hypertensives (31 +/- 6 fmol/ml) and normotensives (19 +/- 3 fmol/ml).
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Mean plasma ir-acth, plasma cortisol, and urinary cortisol levels did not differ significantly between any of these groups. cost generic viagra In order to evaluate the effect of a pro-gamma-msh in vitro, adrenal adenoma tissue was obtained from two patients, one with elevated ir-gamma-msh (61 fmol/ml) and a second with low ir-gamma-msh (12 fmol/ml).
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Aldosterone secretion by dispersed adenoma cells from the former, but not the latter, underwent a fourfold dose-dependent (10(-14)-10(-9) m) increase in response to human lys-gamma 3-msh. is there a drug like viagra for women These data suggest that a pro-gamma-msh may be implicated as a pathogenic factor in a subset of patients with primary aldosteronism, particula.
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